Fluconazole - Oral | HealthLink BC (2023)

Pronunciation: floo-KON-a-zole

Common Brand Name(s): Diflucan

Important: How To Use This Information

This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.


Fluconazole is used to prevent and treat a variety of fungal and yeast infections. It belongs to a class of drugs called azole antifungals. It works by stopping the growth of certain types of fungus.

How To Use

Read the Patient Information Leaflet if available from your pharmacist before you start taking fluconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

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Take this medication by mouth with or without food as directed by your doctor, usually once daily.

If you are taking the liquid suspension form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your medical condition and response to treatment. For children, dosage is also based on weight. Generally in children, the dose should not exceed 600 milligrams daily unless directed by the doctor.

This medication works best when the amount of medicine in your body is kept at a constant level. Therefore, take it at the same time each day as directed.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow the fungus to continue to grow, which may result in a return of the infection.

Tell your doctor if your condition persists or if it worsens.

Side Effects

Nausea, vomiting, diarrhea, stomach upset/pain, headache, dizziness, or hair loss may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including:

  • signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss)

Get medical help right away if any of these rare but serious side effects occur:

  • fast/irregular heartbeat
  • severe dizziness
  • fainting

This drug may rarely cause serious liver disease. Get medical help right away if you develop any signs of liver disease, including:

  • severe stomach/abdominal pain
  • persistent nausea/vomiting
  • yellowing eyes/skin
  • dark urine

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

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  • fever that doesn't go away
  • new or worsening lymph node swelling
  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before taking fluconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungal drugs (such as ketoconazole, itraconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • liver disease
  • kidney disease

Fluconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using fluconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions:

  • certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG)
  • family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death)

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using fluconazole safely.

Although uncommon, this drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially rash, vomiting, diarrhea, and QT prolongation (see above).

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During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby if taken during the first 3 months of pregnancy. Ask about reliable forms of birth control while using this medication and for 1 week after stopping treatment. For the treatment of vaginal yeast infections, medications applied in or around the vagina should be considered before this medication. Discuss the risks and benefits with your doctor.

Fluconazole passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Products that may interact with this drug include:

  • clopidogrel

Many drugs besides fluconazole may affect the heart rhythm (QT prolongation), including pimozide, quinidine, macrolide antibiotics (such as erythromycin), among others.

Fluconazole can slow down the removal of other medications from your body, which can affect how they work. Examples of affected drugs include asunaprevir, cisapride, flibanserin, lomitapide, among others.


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: hallucinations, mental/mood changes.


Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

Laboratory and/or medical tests (such as liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

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Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.


Store the tablets at room temperature away from light and moisture. Do not store in the bathroom.

Store the liquid suspension at room temperature or in the refrigerator. Do not freeze. Discard any unused medication after 14 days.

Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised February 2020.

Copyright(c) 2021 First Databank, Inc.

Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed ata provider and is not for distribution, except as may be authorized by the applicable terms of use.

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Conditions of use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information in not intend to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed in indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.


Can you buy fluconazole pills over the counter? ›

No, Diflucan is not available over the counter and is prescription only. Diflucan OTC is not available in the U.S. If you are suffering from yeast infection symptoms, you can book an appointment with one of our doctors today.

Can you take fluconazole orally? ›

You can take fluconazole capsules and liquid with or without food. Fluconazole capsules are either 50mg, 150mg or 200mg. Swallow the capsules whole with a drink of water. It is best to take your capsules at the same time each day.

Does fluconazole 150 mg need prescription? ›

This medicine works by killing the fungus or yeast, or preventing its growth. Fluconazole is also used to prevent candidiasis in patients having bone marrow transplants who receive cancer or radiation treatment. This medicine is available only with your doctor's prescription.

Can I take fluconazole 150 mg everyday? ›

by Drugs.com

If symptoms continue despite appropriate treatment, fluconazole may be prescribed for every day use for ten to fourteen days, and even continued once per week for six months. Fluconazole is an antifungal medicine and is used to treat infections caused by fungus.

Can you get Diflucan over the counter in Canada? ›

Non-prescription (oral, 150 mg) fluconazole products are authorized for sale in Canada to treat vaginal yeast infections (i.e., vaginal candidiasis). The consumer information for these products recommends not to use them during pregnancy.

What is a substitute for fluconazole? ›

Recommended alternatives for fluconazole-refractory disease include itraconazole, voriconazole, caspofungin, micafungin, anidulafungin, and amphotericin B.

What happens if I take fluconazole without a yeast infection? ›

If you don't really have a yeast infection, antifungals won't help you get better. They can actually prolong the real problem, because while you'll think you're treating the issue, the real cause will continue to develop.

How often can I take oral fluconazole? ›

Adults—150 milligrams (mg) once a day.

What should I avoid while taking fluconazole? ›

Common medications that may interact with fluconazole include: anticoagulants or antiplatelet agents (blood thinners), such as warfarin, and clopidogrel (may prolong bleeding time) biologics, such as acalabrutinib, bosutinib, or entrectinib. albuterol.

Can I buy fluconazole at pharmacy? ›

Although this is a prescription medication, you can buy Diflucan over-the-counter. This preparation is available in any local pharmacy.

Is 150 mg fluconazole enough to treat yeast infection? ›

Oral fluconazole given in a single dose of 150 mg is an effective, safe and well tolerated treatment for vaginal candidiasis.

Is Diflucan the same as fluconazole? ›

Fluconazole is used to treat vaginal yeast infections. It works by stopping the growth of common types of vaginal yeast (fungus). This medication belongs to a class of drugs called azole antifungals. Fluconazole is available under the following different brand names: Diflucan.

What is the best time of day to take fluconazole? ›

Fluconazole can be taken at any time of day, and can be taken either before or after a meal. Swallow the capsule with a drink of water. Infections such as vaginal thrush can be treated with a single 150 mg dose; other infections require a course of treatment possibly lasting a number of weeks.

Can fluconazole be harmful? ›

Serious skin reactions can occur in certain people during treatment with this medicine. Check with your doctor right away if you or your child start having a skin rash, itching, or any other skin changes while using this medicine. Contact your doctor right away if you have any changes to your heart rhythm.

Can I take fluconazole for 2 days? ›

Diflucan dosage

One dose of Diflucan is usually all it takes to cure a yeast infection. This is because the medication stays in vaginal secretions for at least 72 hours. In certain people who have symptoms that persist after one dose of Diflucan, a further dose can be taken every three days for a total of three doses.

How much is Diflucan at Walmart without insurance? ›

Average 12 Month Prices for Diflucan (Brand) & Fluconazole (Generic)
PharmacyDiflucan Retail PriceFluconazole Retail Price
Kroger Pharmacy$76.99$12.00
Albertsons Pharmacy-$15.72
2 more rows

Is there a stronger antifungal than fluconazole? ›

Relapse was observed in 9 (28.5%) and 16 (53%) of the cured cases in Group 1 and Group 2 respectively. Conclusion: Itraconazole was found to be more effective in the treatment of vulvovaginal candidiasis compared to fluconazole with high cure and low relapse rate.

What is the strongest medication for oral thrush? ›

Moderate to severe oral thrush

The first-choice oral option is fluconazole (Diflucan). It's available as tablets or a liquid suspension. If fluconazole doesn't work or you have a bad reaction to it, itraconazole solution (Sporanox) and posaconazole suspension (Noxafil) are alternative options.

Is there a non prescription pill for yeast infection? ›

Most yeast infection suppositories and preventive probiotics are available as OTC treatments. However, yeast infection pills such as fluconazole are only available through prescription.

How quickly does fluconazole work? ›

Fluconazole 150 mg capsules are an antifungal medication used to treat vaginal yeast infections caused by the yeast known as Candida. It works by stopping the growth of Candida. It usually starts to work within one day, but it may take 3 days for your symptoms to improve and up to 7 days for your symptoms to disappear.

What can be mistaken for a yeast infection? ›

8 Common Conditions Often Mistaken for a Yeast Infection
  • Bacterial vaginosis (BV) ...
  • Cytolytic Vaginosis (CV) ...
  • Allergic reaction (contact dermatitis) ...
  • Genital herpes. ...
  • Genital warts. ...
  • Trichomoniasis ("trich") ...
  • Gonorrhea‍ ...
  • Hemorrhoids.

Can fluconazole throw off your pH balance? ›

During maintenance treatment with fluconazole, the pH dropped significantly to 4.5±0.8 (p=0.01). Depression of Lactobacilli spp. (increased lactobacillary grades) was more frequent during the acute, pre-treatment period (30.0%) than during the treatment period (23.1%, p=0.03).

Can I take fluconazole for 4 days? ›

You should continue to take fluconazole for as long as your healthcare provider recommends, even if you start to feel better before your prescription is finished. Fluconazole is usually taken once a day at the same time each day. It can be taken with or without food.

What infections does fluconazole treat? ›

Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and ...

Does fluconazole flush out yeast? ›

Official answer. Fluconazole inhibits the growth of the yeast Candida albicans, which is most commonly responsible for vaginal yeast infections. This allows our body's defenses to eliminate the fungus and resolve the discharge.

Can you drink coffee with fluconazole? ›

Fluconazole (Diflucan) interacts with COFFEE

Fluconazole might decrease how quickly the body gets rid of caffeine. Taking fluconazole and drinking coffee might increase the risk of caffeine side effects, including jitteriness and fast heartbeat.

Why is fluconazole given once a week? ›

Conclusion: Fluconazole administered once weekly is safe and effective in eradicating distal subungual onychomycosis of the fingernail caused by dermatophytes.

How much does fluconazole cost at the pharmacy? ›

Average 12 Month Prices for Diflucan (Brand) & Fluconazole (Generic)
PharmacyDiflucan Retail PriceFluconazole Retail Price
CVS Pharmacy$84.86$16.50
Kroger Pharmacy$76.99$12.00
2 more rows

What is the generic for fluconazole? ›

What is fluconazole? Fluconazole is a prescription drug. It comes as a tablet or suspension you take by mouth. Fluconazole oral tablet is available as both a generic drug and as the brand-name drug Diflucan.

How much is Diflucan over the counter? ›

The cost for Diflucan oral tablet 100 mg is around $45 for a supply of 30 tablets, depending on the pharmacy you visit.

What is the one time pill for yeast infection? ›

Fluconazole (Diflucan) is a single dose pill which kills fungus and yeast throughout your body.

Why am I still itchy after taking Diflucan? ›

A skin rash or itching is a common side effect of Fluconazole. You do not need to be concerned unless you start feeling symptoms of an allergic reaction: swelling of your face, lips, tongue, or throat, hives or difficulty breathing; in which case you should get to an emergency department immediately.

Does fluconazole make you sleep? ›

Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally.

Can you take fluconazole every 3 days? ›

How are they treated? Recurrent vaginal yeast infections may be treated with: Fluconazole. You take a 150 mg dose of fluconazole by mouth, once every 3 days for three doses.

How common are side effects of fluconazole? ›

The following treatment-related clinical adverse events occurred at an incidence of 1% or greater in 4048 patients receiving DIFLUCAN for 7 or more days in clinical trials: nausea 3.7%, headache 1.9%, skin rash 1.8%, vomiting 1.7%, abdominal pain 1.7%, and diarrhea 1.5%.

Is fluconazole hard on the liver? ›

Fluconazole is a triazole fungistatic agent used in the treatment of systemic and superficial fungal infections. Fluconazole therapy can cause transient mild-to-moderate serum aminotransferase elevations and is a known cause of clinically apparent acute drug induced liver injury.

Does fluconazole cause hair loss? ›

Alopecia developed a median of 3 months after initiation of fluconazole therapy and involved the scalp in all patients. Other sites were involved in about one third of patients. Three patients required wigs because of extensive hair loss.

How long does it take for fluconazole pill to work? ›

Fluconazole 150 mg capsules are an antifungal medication used to treat vaginal yeast infections caused by the yeast known as Candida. It works by stopping the growth of Candida. It usually starts to work within one day, but it may take 3 days for your symptoms to improve and up to 7 days for your symptoms to disappear.

Is fluconazole risky? ›

There are concerns that fluconazole use may be associated with stillbirth, particularly in doses above those commonly used for the treatment of vaginal candidiasis (150 mg, administered once or twice).

What happens if you take fluconazole without yeast infection? ›

If you don't really have a yeast infection, antifungals won't help you get better. They can actually prolong the real problem, because while you'll think you're treating the issue, the real cause will continue to develop.

How many fluconazole 200 mg should I take? ›

For esophageal candidiasis: Adults—200 milligrams (mg) on the first day, followed by 100 mg once a day for at least 3 weeks. Your doctor may increase your dose as needed. Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor.


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