Fluconazole (Oral Route) Precautions - Mayo Clinic (2023)

Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Diflucan

Canadian Brand Name

  1. CanesOral

Descriptions

Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and infections that may occur in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast, or preventing its growth.

Fluconazole is also used to prevent candidiasis in patients having bone marrow transplants who receive cancer or radiation treatment.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Powder for Suspension

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluconazole in children 6 months to 13 years of age. However, safety and efficacy have not been established in children younger than 6 months of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluconazole in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving fluconazole.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Alfuzosin
  • Amiodarone
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Artemether
  • Atazanavir
  • Bedaquiline
  • Bepridil
  • Buprenorphine
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Dofetilide
  • Domperidone
  • Donepezil
  • Dronedarone
  • Eliglustat
  • Encorafenib
  • Entrectinib
  • Erythromycin
  • Escitalopram
  • Fexinidazole
  • Flibanserin
  • Fostemsavir
  • Glasdegib
  • Granisetron
  • Haloperidol
  • Iloperidone
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Levoketoconazole
  • Levomethadyl
  • Lomitapide
  • Lumefantrine
  • Macimorelin
  • Mavacamten
  • Mefloquine
  • Mesoridazine
  • Methadone
  • Mifepristone
  • Mirtazapine
  • Mobocertinib
  • Nilotinib
  • Ondansetron
  • Osilodrostat
  • Pacritinib
  • Panobinostat
  • Pazopanib
  • Pimavanserin
  • Pimozide
  • Piperaquine
  • Pitolisant
  • Propafenone
  • Quetiapine
  • Quinidine
  • Quinine
  • Ribociclib
  • Ritonavir
  • Saquinavir
  • Selpercatinib
  • Solifenacin
  • Sorafenib
  • Sparfloxacin
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telaprevir
  • Telithromycin
  • Thioridazine
  • Toremifene
  • Trazodone
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vilanterol
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abrocitinib
  • Acalabrutinib
  • Acenocoumarol
  • Ajmaline
  • Alfentanil
  • Alprazolam
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Anisindione
  • Apixaban
  • Apomorphine
  • Aprepitant
  • Aprindine
  • Arsenic Trioxide
  • Asenapine
  • Atorvastatin
  • Avapritinib
  • Avatrombopag
  • Azilsartan
  • Azilsartan Medoxomil
  • Azithromycin
  • Belzutifan
  • Benzhydrocodone
  • Bosutinib
  • Bretylium
  • Brexpiprazole
  • Brigatinib
  • Buserelin
  • Carbamazepine
  • Carvedilol
  • Ceritinib
  • Cerivastatin
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cilostazol
  • Ciprofloxacin
  • Clofazimine
  • Clomipramine
  • Clopidogrel
  • Clothiapine
  • Cobimetinib
  • Codeine
  • Colchicine
  • Conivaptan
  • Cyclobenzaprine
  • Cyclosporine
  • Daridorexant
  • Deflazacort
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dexmedetomidine
  • Dibenzepin
  • Dicumarol
  • Dihydrocodeine
  • Dihydroergotamine
  • Disopyramide
  • Dolasetron
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Ebastine
  • Efavirenz
  • Elexacaftor
  • Enflurane
  • Eplerenone
  • Ergoloid Mesylates
  • Ergonovine
  • Ergotamine
  • Eribulin
  • Famotidine
  • Felbamate
  • Fentanyl
  • Finerenone
  • Fingolimod
  • Flecainide
  • Fluoxetine
  • Fluvastatin
  • Formoterol
  • Fosaprepitant
  • Foscarnet
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Halothane
  • Histrelin
  • Hydrocodone
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibrutinib
  • Ibutilide
  • Ifosfamide
  • Imipramine
  • Infigratinib
  • Inotuzumab Ozogamicin
  • Irbesartan
  • Isoflurane
  • Isradipine
  • Ivacaftor
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Leuprolide
  • Levofloxacin
  • Levomilnacipran
  • Lidoflazine
  • Lofexidine
  • Lopinavir
  • Lorcainide
  • Lorlatinib
  • Lumateperone
  • Lurasidone
  • Lurbinectedin
  • Macitentan
  • Meperidine
  • Mephenytoin
  • Meprobamate
  • Methotrimeprazine
  • Methylergonovine
  • Metronidazole
  • Milnacipran
  • Mitapivat
  • Mizolastine
  • Moricizine
  • Moxifloxacin
  • Nafarelin
  • Naloxegol
  • Nevirapine
  • Nisoldipine
  • Nitrofurantoin
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olaparib
  • Osimertinib
  • Ospemifene
  • Oxaliplatin
  • Oxycodone
  • Ozanimod
  • Paclitaxel
  • Paliperidone
  • Papaverine
  • Parecoxib
  • Paroxetine
  • Pasireotide
  • Pemigatinib
  • Pentamidine
  • Pentazocine
  • Perphenazine
  • Pexidartinib
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Pipamperone
  • Pirmenol
  • Ponesimod
  • Posaconazole
  • Prajmaline
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Protriptyline
  • Ranolazine
  • Rifabutin
  • Rimegepant
  • Risperidone
  • Ruxolitinib
  • Selumetinib
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sildenafil
  • Simeprevir
  • Simvastatin
  • Siponimod
  • Sirolimus
  • Sirolimus Protein-Bound
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Sonidegib
  • Sotalol
  • Spiramycin
  • Sufentanil
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Tazemetostat
  • Telavancin
  • Temsirolimus
  • Tetrabenazine
  • Tezacaftor
  • Theophylline
  • Ticagrelor
  • Tolterodine
  • Tolvaptan
  • Torsemide
  • Tramadol
  • Triazolam
  • Triclabendazole
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Ubrogepant
  • Valdecoxib
  • Venetoclax
  • Venlafaxine
  • Vinblastine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vorinostat
  • Vortioxetine
  • Warfarin
  • Zanubrutinib
  • Zolmitriptan
  • Zotepine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amlodipine
  • Atevirdine
  • Celecoxib
  • Cimetidine
  • Etravirine
  • Felodipine
  • Fosphenytoin
  • Losartan
  • Midazolam
  • Nicardipine
  • Omeprazole
  • Phenytoin
  • Prednisone
  • Ramelteon
  • Rifampin
  • Rifapentine
  • Suvorexant
  • Tipranavir
  • Tofacitinib
  • Tretinoin
  • Trimetrexate
  • Zidovudine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Electrolyte problems (mineral imbalance) or
  • Heart disease—Use with caution. These conditions may increase your risk of having heart rhythm problems and make the effects of this medicine worse.
  • Fructose malabsorption (rare hereditary problem) or
  • Glucose-galactose malabsorption (rare hereditary problem) or
  • Sucrase-isomaltase deficiency (rare hereditary problem)—Should not be used in patients with these conditions. Oral liquid contains sucrose (table sugar).
  • Heart rhythm problems (eg, QT prolongation) or
  • Liver disease—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

You may take this medicine with or without food.

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Shake the oral liquid well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (suspension or tablets):
    • For cryptococcal meningitis:
      • Adults—400 milligrams (mg) on the first day, followed by 200 mg once a day for at least 10 to 12 weeks. Your doctor may adjust your dose as needed.
      • Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 12 milligrams (mg) per kilogram (kg) of body weight on the first day, followed by 6 mg per kg of body weight once a day, for at least 10 to 12 weeks.
      • Children younger than 6 months of age—Use and dose must be determined by your doctor.
    • For esophageal candidiasis:
      • Adults—200 milligrams (mg) on the first day, followed by 100 mg once a day for at least 3 weeks. Your doctor may increase your dose as needed.
      • Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 milligrams (mg) per kilogram (kg) of body weight on the first day, followed by 3 mg per kg of body weight once a day, for at least 3 weeks.
      • Children younger than 6 months of age—Use and dose must be determined by your doctor.
    • For oropharyngeal candidiasis:
      • Adults—200 milligrams (mg) on the first day, followed by 100 mg once a day for at least 2 weeks.
      • Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 milligrams (mg) per kilogram (kg) of body weight on the first day, followed by 3 mg per kg of body weight once a day, for at least 2 weeks.
      • Children younger than 6 months of age—Use and dose must be determined by your doctor.
    • For other infections that may occur in different parts of the body:
      • Adults—Doses of up to 400 milligrams (mg) per day.
      • Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 to 12 milligrams (mg) per kilogram (kg) of body weight per day.
      • Children younger than 6 months of age—Use and dose must be determined by your doctor.
    • For prevention of candidiasis during bone marrow transplantation:
      • Adults—400 milligrams (mg) once a day.
      • Children—Use and dose must be determined by your doctor.
    • For urinary tract infections or peritonitis:
      • Adults—50 to 200 milligrams (mg) per day.
      • Children—Use and dose must be determined by your doctor.
    • For vaginal candidiasis:
      • Adults—150 milligrams (mg) once a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

The mixed oral liquid should be kept in the refrigerator or at room temperature and used within 14 days. Do not freeze.

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

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If your or your child's symptoms do not improve, or if they become worse, check with your doctor. Continue to take this medicine as directed.

You or your child should not use erythromycin (Ery-Tab®), pimozide (Orap®), or quinidine (Cardioquin®) while using this medicine because of the risk of unwanted side effects.

Using this medicine for a long time or using it too much while you are pregnant (especially during the first trimester) can harm your unborn baby. Use an effective form of birth control during treatment with this medicine and for at least 1 week after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may rarely cause serious liver problems. Check with your doctor right away if you or your child have stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin.

This medicine may rarely cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble with breathing, trouble with swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions can occur in certain people during treatment with this medicine. Check with your doctor right away if you or your child start having a skin rash, itching, or any other skin changes while using this medicine.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem including QT prolongation.

This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

  1. Chest tightness
  2. chills
  3. clay-colored stools
  4. cough
  5. dark urine
  6. diarrhea
  7. difficulty with swallowing
  8. dizziness
  9. fast heartbeat
  10. fever
  11. headache
  12. hives, itching, or skin rash
  13. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  14. light-colored stools
  15. loss of appetite
  16. nausea
  17. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  18. stomach pain, continuing
  19. unpleasant breath odor
  20. unusual tiredness or weakness
  21. upper right abdominal or stomach pain
  22. vomiting
  23. vomiting of blood
  24. yellow eyes and skin

Incidence not known

  1. Black, tarry stools
  2. blistering, peeling, or loosening of the skin
  3. chest pain or discomfort
  4. decreased urine
  5. dry mouth
  6. fainting
  7. hoarseness
  8. increased thirst
  9. irregular or slow heart rate
  10. joint or muscle pain
  11. loss of bladder control
  12. lower back or side pain
  13. mood changes
  14. muscle pain or cramps
  15. muscle spasm or jerking of the arms and legs
  16. numbness or tingling in the hands, feet, or lips
  17. painful or difficult urination
  18. pale skin
  19. red skin lesions, often with a purple center
  20. red, irritated eyes
  21. seizures
  22. sore throat
  23. sores, ulcers, or white spots in the mouth or on the lips
  24. sudden loss of consciousness
  25. swollen glands
  26. unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Fearfulness, suspiciousness, or other mental changes
  2. seeing, hearing, or feeling things that are not there

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Belching
  2. change in taste or bad, unusual, or unpleasant (after) taste
  3. heartburn
  4. indigestion
  5. stomach discomfort or upset

Incidence not known

  1. Hair loss or thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: Nov. 01, 2022

Original article: https://www.mayoclinic.org/drugs-supplements/fluconazole-oral-route/precautions/drg-20071428

Copyright © 2022 IBM Watson Health. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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FAQs

Is fluconazole taken by mouth? ›

Brand name: Diflucan.

Fluconazole comes as a tablet or suspension you take by mouth. It also comes in an injectable form that can only be given to you by a healthcare professional. Fluconazole oral tablet is used to prevent and treat candidiasis, a fungal infection.

How do you administer fluconazole orally? ›

Take this medication by mouth with or without food as directed by your doctor, usually once daily. If you are taking the liquid suspension form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon.

What are the precaution of fluconazole? ›

This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

Is fluconazole active by oral route? ›

DIFLUCAN® (fluconazole), the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration, as a powder for oral suspension.

What is the route of fluconazole? ›

Fluconazole may be administered either orally or by intravenous infusion. The route of administration selection will depend on the clinical condition of the patient.

What are the side effects of oral fluconazole? ›

Side Effects
  • Chest tightness.
  • clay-colored stools.
  • difficulty with swallowing.
  • fast heartbeat.
  • hives, itching, or skin rash.
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals.
  • light-colored stools.
  • stomach pain, continuing.

How do you administer an oral capsule? ›

Place the tablet on your tongue and close your mouth around the opening of the bottle. Tilt your head back and keep your mouth sealed around the water bottle. Don't let any air into your mouth. Suck the water into your mouth and swallow the tablet and water.

How do you take oral thrush tablets? ›

It's less common than in women, but men can also suffer from thrush symptoms.
  1. Canesten® Oral Capsule can provide an effective treatment for men with thrush infections.
  2. Usage: take the oral capsule with a glass of water, with or without food.

How do you administer a yeast infection pill? ›

If you are using it with an applicator, unwrap the tablet and place the flat end of the suppository into the open end of the applicator. Then, lie on your back with knees drawn up toward your chest. Gently insert the applicator high into the vagina and push the plunger to release the tablet.

What precautions should be taken to avoid fungal infection? ›

Prevention
  1. Be sure to practice good hygiene.
  2. Don't share clothing, towels, or other personal items.
  3. Wear clean clothes every day, particularly socks and underwear.
  4. Choose clothing and shoes that breathe well. ...
  5. Make sure to dry off properly with a clean, dry, towel after showering, bathing, or swimming.
7 Jan 2020

What are the precautions for yeast infection? ›

  • Wear breathable underwear. Cotton is your best choice. ...
  • Keep things loose. ...
  • Don't douche. ...
  • Avoid hot tubs and extra hot baths. ...
  • Change out of wet clothes. ...
  • In the bathroom, always wipe from front to back.
  • When on your period, change your tampons, pads, and panty liners often.
  • Manage your diabetes.
20 Sept 2021

Why is fluconazole considered hazardous? ›

Known Clinical Effects: Adverse effects most commonly reported in clinical use include skin rash, headache, nausea, and abdominal pain. Rare cases of serious liver damage and allergic reactions have been reported.

Which antifungal drug is administered only by oral route? ›

oral antifungal medications such as itraconazole (Sporanox), fluconazole (Diflucan), or prescription-strength terbinafine (Lamisil)

How often can I take oral fluconazole? ›

If symptoms continue despite appropriate treatment, fluconazole may be prescribed for every day use for ten to fourteen days, and even continued once per week for six months. Fluconazole is an antifungal medicine and is used to treat infections caused by fungus.

Is fluconazole oral or topical? ›

Fluconazole comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken once a day, with or without food.

Is fluconazole oral or IV? ›

Fluconazole administration requires multiple doses except in vaginal candidiasis, where the recommended dosage is 150 mg as a single oral dose.

What is oral fluconazole? ›

Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and ...

What do I need to know before taking fluconazole? ›

A headache, nausea, abdominal pain, diarrhea, indigestion, and dizziness. The incidence of gastrointestinal side effects is high with single-dose therapy. Anaphylaxis and a rash have been reported rarely. In some people, fluconazole may cause dizziness and affect their ability to drive a car or operate machinery.

What are three possible side effects of oral antifungals? ›

Occasionally, antifungal medicines may cause a more severe reaction, such as: an allergic reaction – your face, neck or tongue may swell and you may have difficulty breathing.
...
Side effects of antifungal medicines
  • itching or burning.
  • redness.
  • feeling sick.
  • tummy (abdominal) pain.
  • diarrhoea.
  • a rash.

When do fluconazole side effects start? ›

Fluconazole side effects such as headache, nausea, and stomach pain can start quickly when given an injection. When fluconazole is taken by mouth, minor side effects could appear within an hour or two, the amount of time it normally takes an oral dose of fluconazole to hit its peak in the bloodstream.

What medications should not be taken with fluconazole? ›

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with fluconazole.
  • cisapride, fentanyl, methadone, pimozide, tofacitinib, tolvaptan, or a vitamin A supplement;
  • an antibiotic, antifungal, or antiviral medicine;
  • a blood thinner;
  • cancer medicine;
  • cholesterol medication;

What is the safest way to administer oral medication? ›

Administer medication orally as prescribed. Tablets: place in mouth and swallow using water or other oral fluids. Orally disintegrating medications: Remove carefully from packaging. Place medication on top of patient's tongue, and have patient avoid chewing the medication.

How do you give oral liquid medication? ›

Put the top back on the bottle. Put the tip of the oral syringe inside your child's mouth between the gums and the inside surface of their cheek. Gently push the plunger to squirt small amounts of medicine into the side of your child's mouth. Allow your child to swallow before you carry on pushing the plunger.

Are pill capsules supposed to be opened before swallowing? ›

When taking a prescription drug, you should never crush a tablet, open a capsule or chew either without first asking the prescribing health care provider or dispensing pharmacist whether it is safe to do so.

How do you take fluconazole 100 mg for oral thrush? ›

Dosing
  1. Adults—200 milligrams (mg) on the first day, followed by 100 mg once a day for at least 3 weeks. ...
  2. Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. ...
  3. Children younger than 6 months of age—Use and dose must be determined by your doctor.

Can you take fluconazole 150 mg for oral thrush? ›

Conclusion: Single-dose fluconazole 150 mg is an effective treatment of oral thrush for individuals with advanced cancer.

Is fluconazole pill enough for oral thrush? ›

A single 750 milligram dose of Diflucan (fluconazole) is as safe and effective as taking 150 mg of Diflucan once daily for 14 days in curing oral candidiasis, also known as thrush, according to a study in the October 7 issue of Clinical Infectious Diseases.

How often can you take fluconazole for yeast infection? ›

How are they treated? Recurrent vaginal yeast infections may be treated with: Fluconazole. You take a 150 mg dose of fluconazole by mouth, once every 3 days for three doses.

When should I take fluconazole? ›

Fluconazole can be taken at any time of day, and can be taken either before or after a meal. Swallow the capsule with a drink of water. Infections such as vaginal thrush can be treated with a single 150 mg dose; other infections require a course of treatment possibly lasting a number of weeks.

How many days do you take yeast infection pills? ›

One, three, and seven-day treatments are equally effective. The length of treatment depends on how severe your infection is. Oral treatment — A prescription pill called fluconazole (sample brand name: Diflucan) is another option for treating yeast infections.

Do and don'ts for fungal infection? ›

Fungal diseases can spread from person to person.
...
Dos and Don'ts.
Do'sDon'ts
Keep hands cleanWear jeans and undergarments that are tight
Wash clothes in hot water every day, sun dry, and iron before wearingUse steroid creams without discussing with a doctor
Wear comfortable cotton clothesShare towels, napkins, or other clothes
1 more row

What should you not do if you have a fungal infection? ›

DON'Ts
  • Wear tight and wet clothes.
  • Do manicures and pedicures especially in the rainy season.
  • Share towels, napkins, or other clothes.
  • Self-treat a fungal infection. It is best to reach out to a doctor in case you notice one.
  • Use steroid creams without consulting a doctor.
16 Jul 2020

What increases risk of fungal infection? ›

Immunosuppression and breakdown of anatomical barriers such as the skin are the major risk factors for fungal infections. Health care workers encounter at-risk patients in various settings, including AIDS clinics and intensive care, transplantation and oncology units.

Can you take a bath with a yeast infection? ›

As a rule, showers are better than baths when you're in the process of treating a yeast infection. If you do take a sitz bath with Epsom salt, apple cider vinegar, boric acid, or any other home remedy while you're treating your yeast infection, don't soak for more than 10 minutes at a time.

What foods to avoid if you have a yeast infection? ›

List of Foods to avoid with a yeast infection:
  • In vegetables: Potatoes, corn, beans, and peas.
  • In fruits: High-sugar fruits like bananas, mangoes, figs, and raisins.
  • Caffeinated coffee and tea, sugar-sweetened beverages, and alcohol-type beverages.
  • Processed meats and farm-raised fish.
7 Aug 2022

How do you prevent a yeast infection when taking antibiotics? ›

Use an over-the-counter antifungal

Using an over-the-counter (OTC) antifungal cream or suppository can help prevent yeast infections caused by antibiotics. Antifungal agents can take the place of your good bacteria, working to keep yeast in check.

Can fluconazole be toxic? ›

The FDA label warns that this drug carries a risk of hepatotoxicity. Rare but serious cases of serious hepatic toxicity have been reported, especially in patients with serious underlying medical conditions using fluconazole. This group of patients has an increased risk of fatality when using fluconazole.

Is fluconazole cytotoxic? ›

Our experiments showed that fluconazole is cytotoxic and genotoxic in the assessed conditions. It is likely that such effects may be due to the oxidative properties of fluconazole and/or the presence of FMO (flavin-containing monooxygenase) in Vero cells.

Why are antifungals so toxic? ›

For example, the 2 most common classes of antifungal agents, polyenes and azoles, target the synthesis of the cell membrane, a structure shared by both mammalian and fungal cells, and thus these drugs have inherent toxicity.

Which drug Cannot be given by oral route? ›

Commonly used drugs that undergo extensive first pass metabolism are cimetidine, lidocaine, propranolol, nitroglycerin, diazepam, midazolam, morphine, pethidine, imipramine, and buprenorphine. Some drugs like insulin are destroyed by the gastric secretions and therefore cannot be given orally.

What type of drugs Cannot be given by oral route? ›

However, oral route has few limitations like slow onset of action, and thus cannot be given in emergencies, unpalatable/irritant drugs (e.g., chlora m phenicol), unabsorbable drugs (e.g., neomycin), drugs with high firstpass metabolism (e.g., lignocaine), medications destroyed by digestive juices (e.g., insulin).

Why is the oral route the preferred route for medications? ›

Oral medication is the most common form of drug administration because of advantages such as convenience of drug administration via the oral route, patient preference, cost-effectiveness, and ease of large-scale manufacturing of oral dosage forms.

How long can you take fluconazole daily? ›

It could be a single dose, or treatment for several weeks, months or even years. If your doctor prescribes a course of fluconazole, they will advise you how long to take it for. Keep taking your medicine until the course is finished, even if you start to feel better. This will help to stop the infection coming back.

Can you take fluconazole at any time of day? ›

It doesn't matter what time you take it. But if you take it for more than one dose, you should take it at the same time each day. This will help you remember to take it. It will also ensure that you have a good amount of fluconazole in your body at all times to treat your infection.

Can you overuse fluconazole? ›

There have been reports of overdose with fluconazole accompanied by hallucination and paranoid behavior. In the event of overdose, symptomatic treatment (with supportive measures and gastric lavage if clinically indicated) should be instituted. Fluconazole is largely excreted in urine.

Is fluconazole topical or oral? ›

Although topical regimens are commonly, used oral treatment is preferred by patients because of the ease of administration and the reduced duration of use [7]. fluconazole is a triazole antifungal agent introduced in the early 1990s which has a good safety profile and is the most widely used antifungal agent for VVC.

What is the best time of day to take fluconazole? ›

Fluconazole can be taken at any time of day, and can be taken either before or after a meal. Swallow the capsule with a drink of water. Infections such as vaginal thrush can be treated with a single 150 mg dose; other infections require a course of treatment possibly lasting a number of weeks.

What is oral fluconazole used for? ›

Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and ...

Can antifungal be taken orally? ›

Antifungal drugs are very diverse. They can be given orally, as a topical treatment, or via IV.

What is the difference between topical and oral? ›

There are many differences between topical drug administration and oral administration. The primary difference is topically formulated drugs are applied to the external parts of the body as opposed to ingestion by mouth.

Is fluconazole topical or systemic? ›

Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues.

Is topical the same as oral? ›

The primary difference between these two classes of medication is that oral medication affects the entire body's sensitivity to pain, while topical medication only relieves pain in a specific area of the body.

What happens if you take fluconazole on an empty stomach? ›

You can take fluconazole with or without food. The most common side effects of fluconazole are feeling sick (nausea) and diarrhoea.

Do you take fluconazole before or after food? ›

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. You may take this medicine with or without food.

Can fluconazole cause bleeding? ›

Stop taking Fluconazole 150 mg Capsules and seek medical attention immediately if you notice any of the symptoms related to these serious skin reactions described in section 4. have any abnormal or irregular vaginal bleeding or a blood stained discharge. have vulval or vaginal sores, ulcers or blisters.

Does fluconazole raise blood pressure? ›

In the present study, a significant decrease of blood pressure was observed after the start of the administration of fluconazole.

Are oral antifungals harmful? ›

Rarely, an antifungal drug may cause serious problems like: Liver damage (jaundice). Severe allergic reactions like anaphylaxis. Severe allergic skin reactions, such as blisters and peeling skin.

Are oral antifungals toxic? ›

The authors concluded that oral antifungal agents are associated with a low incidence of acute liver injury and that it may be fatal, especially for the elderly. They also found that a longer treatment duration may increase the risk of antifungal agent-induced liver injury, especially for ketoconazole [35].

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