The Complete List of Probiotic Side Effects + How to Avoid Them (2023)

We know that probiotics can do many amazing things ranging from helping with weight loss to treating acne and more.

But do all of these benefits come without a cost?

It turns out that some people may be sensitive to certain probiotic species and may react negatively if they are used improperly.

You can prevent theseside effects by taking certain steps which I've outlined in this guide.

Taking these steps will allow you to take full advantage of all of the positive probiotic side effects while avoiding all of the negative ones.

Let's jump in:


Can Probiotics be Harmful?

Whether you realize it or not your gut is home to hundreds of different types of bacteria that all work together to create "you".

Collectively this mass of bacteria is known as the microbiome.

Small changes to certain key bacterial species and concentration(1) can result in big symptoms ranging from weight gain to mood changes like depression.

This connection between your gut bacteria and multiple systems in your body is well known(2) and has been studied intensely by scientists.

The Complete List of Probiotic Side Effects + How to Avoid Them (1)

Recently we've been able to harness the power of probiotics and encapsulate certain bacterial species and mass produce probiotics to help fight and prevent disease.

This has lead to an explosion of probiotic use over time.

But like any therapy, just because it works for some people doesn't necessarily mean it will work for EVERYONE.

(Video) Probiotic Side Effects

In fact, some conditions may actually be worsened by using probiotics (we will talk more about this below).

But there is some good news:

The majority of negative symptoms related to taking probiotics can easily be managed by either changing to a different probiotic or by making a small change like taking your probiotic with a meal.

Side effects usually come from low-quality probiotics or due to one of the following reasons:

  • Low-quality probiotics with unstudied bacterial species and strains
  • Using cheap probiotics that contain fillers or binders
  • Taking your probiotic on an empty stomach
  • A negative reaction to prebiotics that has been included in the probiotic formulation (prebiotics act as food for the bacteria in your gut)
  • Consuming probiotics that have not been temperature controlled or climate controlled (certain bacterial species MUST be refrigerated or they will die)

Very few people have true negative reactions to probiotics.

But, because negative side effects can occur let's talk about what to do if you experience them...

Negative Side Effects of Probiotics

The negative side effects of probiotics usually originate in the gastrointestinal tract.

You can find the most common list of probiotic side effects including what to do about them here:

  • Nausea -> This is usually caused by the production of stomach acid related to taking your probiotics. To reduce the incidence of nausea simply take your probiotics with a meal.
  • Constipation -> Occasionally certain bacterial species (like lactobacilli species) may actually worsen constipation. This is felt to occur in patients who have a condition known as SIBO.
  • Abdominal pain -> If you experience abdominal pain after taking probiotics it is most likely related to gas or bloating (outlined below). Occasionally you might experience some abdominal pain or cramping due to an increase in stomach acid as well which causes "indigestion".
  • *Increased gas or bloating -> Certain probiotics (lactobacilli species) may cause gas and bloating in patients who have existing small intestinal bacterial overgrowth. This symptom is related to the production of gas from existing bacteria in your gut. SIBO is a fairly common conditionand may account for the majority of negative side effects related to taking certain probiotics. If you have SIBO you can avoid these symptoms by taking a soil based organism.
  • Rashes, itching or hives -> Usually related to poor quality ingredients, inactive binders or due to the specific formulation of the probiotic (not the bacteria inside the probiotic). This symptom usually fades when you switch to high-quality probiotics that don't contain low-quality fillers/binders.

The Complete List of Probiotic Side Effects + How to Avoid Them (2)

Most of the symptoms above, with the exception of gas and bloating, usually go away over time.

While some people may experience negative side effects from taking probiotics it's important to also focus on the positive side effects of probiotics - which is why most people take them to begin with!

Special consideration should be given to people with non-existent immune systems or immune function:

There is a theoretical risk of causing infection by using probiotics if you have a severely weakened immune system.

This designation is usually referred to people who are constant oral steroids (prednisone) or patients on chemotherapy.

Patients with autoimmune diseases generally do NOT fall into this category and usually find significant benefit from using probiotics due to their immune-boosting effect (3).

(Video) Probiotics Benefits + Myths | Improve Gut Health | Doctor Mike

Positive Side Effects of Probiotics

People take probiotics because they want to experience some positive benefit or outcome.

It's important to focus on these well documented and very helpful benefits.

Realistically, if you are using high-quality probiotics the chance that you will experience negative side effects is very low.

Below you will find a list of the most common positive side effects that are seen while taking probiotics and why you may experience them:

  • Normalization of bowel movements -> Studies have shown that probiotics have been shown to both reduce diarrhea and reduce constipation(4). This normalization occurs based on what symptom you are currently experiencing.
  • Reduction in acid reflux -> Certain populations of bacteria slow down intestinal motility and reduce gastric emptying. This combination sets the stage for acid reflux as your stomach fills with acid over time. Taking probiotics help reduce the overgrowth of negative bacteria(5) that contribute to this slowing down of the GI tract.
  • Improves absorption of nutrients and vitamins -> Probiotics help digest and break down food products which increase intestinal absorption(6). Probiotics can also reduce intestinal permeability (leaky gut).
  • Improves mood (decreases depression) -> Probiotics have been shown in studies to help directly treat depression and increase the neurotransmitter serotonin (7).
  • Helps with weight loss -> Taking probiotics helps reduce insulin resistance and may help increase your metabolism.
  • Reduction in gas and bloating -> Certain probiotics have been shown to help treat both SIBO and IBS both of which may cause severe gas and bloating.
  • Increases immune function -> Probiotic components help regulate host immune response(8) and have been shown to be helpful in multiple autoimmune conditions (9).
  • Reduces inflammation -> Probiotics help reduce both systemic and local inflammation.

The Complete List of Probiotic Side Effects + How to Avoid Them (3)

Certain species of probiotics such as bifidobacterium tend to provide many of the benefits listed above.

To get these benefits you will want to make sure that you use a high-quality probiotic that contains multiple species and strains at a high enough CFU count.

You can find more information on how to pick out the best probiotic for your body here.

5 Tips to Reduce and Eliminate the Negative Side Effects of Probiotics

If you're one of the few people who has experienced negative side effects while taking probiotics then use these rules to help prevent side effects.

By following these rules you should be able to take advantage of the benefits of probiotics without experience the negative side effects.

#1. Always use High-Quality Probiotics

Remember that quality matters quite a bit when using probiotics.

Certain strains of probiotics have been studied more than others indicating that they are more helpful for certain conditions.

Creating and packaging these specific strains can be expensive.

In addition, it's often cheaper to create supplements if you use inactive binders and fillers to "occupy space".

The unfortunate problem is that many people with gastrointestinal issues tend to react to these binders and fillers.

To avoid these issues you will want to purchase probiotics that do NOT contain inactive fillers, binders, wheat, gluten, dairy, artificial colors, artificial sweeteners or artificial preservatives.

And lastly,you will want to make sure that your probiotics are formulated with a high CFU concentration at the time of manufacturing.

(Video) 5 Possible Side Effects Of Probiotics

If the bottle claims to deliver 10 billion CFU per serving then it will need to be formulated with at least 20 billion CFU at the time of manufacture.

This has to do with the fact that probiotics will die over time unless they have food (prebiotics) to help them survive.

Note that this is only true of certain species.

You can find my recommended brand of probiotics below:

For ultra potency probiotics (greater than 300 billion CFU/serving) consider using a probiotic similar to this one.

For daily general health consider using a probiotic with at least 100 billion CFU per serving like this one.

#2. Take Probiotics both with and without meals

Probiotics can and should be taken both with meals and in between meals.

If you are having issues taking probiotics then switch to taking them with meals.

If you are having issues taking probiotics with meals then you can switch to taking them in between meals.

Each person is slightly different which means that you will have slightly more or less stomach acid compared to your neighbor.

Small changes such as this may cause you to react differently to probiotics when you take them.

#3. Take your probiotics with enzymes

To further reduce the chance of negative side effects you can consider taking enzymes with your probiotics.

Enzymes work synergistically with probiotics and may help to reduce stomach acid production and reduce nausea.

Enzymes help break down foods and nutrients, increase absorption and take some of the demand off of your pancreas which naturally produces pancreatic enzymes.

#4. Consider lowering your Probiotic dose or frequency

Sometimes taking probiotics may be necessary and helpful but certain sensitive people may need to "ease" their way into using them.

If you are a VERY sensitive person (meaning you react to medications, vitamins or supplements) you might find more benefit with reducing your dose or taking your probiotics every other or every third day.

Remember that probiotics act by helping to change the existing microbiome of your intestines.

While changing your microbiome may be helpful it also may take time to adapt to new changes.

(Video) OMG!! 5 Possible Side Effects of Probiotics

Allow time for these changes by reducing how often you take probiotics or by reducing the concentration/dose of your probiotics.

#5. Make sure your probiotics are temperature/climate controlled

Lastly, you will want to make sure that whatever probiotic you decide to use is properly packaged.

Certain probiotic species require specific temperatures for survival.

If your probiotics contain these species and they are shipped without ice packs then the bacteria may be damaged in transit and cause issues.

Note that not all probiotics require temperature control.

I recommend that you find probiotics that are packaged safely to prevent light, moisture, and heat from damaging your probiotics before you even consume them.

Final Thoughts

Taking probiotics may be one of the most helpful things you can do for your body and your health.

Just because probiotics can be helpful doesn't mean they come without side effects.

Luckily, many of these side effects can be avoided by using your probiotics correctly and by purchasing high-quality probiotics.

The only main side effect you want to watch out for is increased gas or bloating while taking probiotics.

The presence of these symptoms may indicate that you have an underlying condition known as small intestinal bacterial overgrowth.

Now I want to hear from you:

Have you experienced any negative symptoms while taking probiotics?

If so, what do you think caused the problem?

Leave your comments below!

References (Click to Expand)

(Video) 4 Possible Side Effects of Eating Probiotics Everyday & How to Manage Them?

The Complete List of Probiotic Side Effects + How to Avoid Them (4)


What to avoid while taking probiotics? ›

Foods That Interfere with Probiotics
  • Carbonated Drinks. Whether you are binging on regular or diet sodas, neither are good for your gut health. ...
  • Processed Foods and Probiotics. ...
  • GMO Products. ...
  • Red Meat. ...
  • Gluten-Rich Foods and Probiotics. ...
  • Refined Oils. ...
  • Dairy Foods and Probiotics. ...
  • Tap Water.
4 Feb 2020

How long does it take for probiotic side effects to go away? ›

Most people do not experience side effects with probiotics -- but if they do, the side effects usually wear off after a few weeks of consistent use (12).

What are the dangers of taking probiotics? ›

Possible harmful effects of probiotics include infections, production of harmful substances by the probiotic microorganisms, and transfer of antibiotic resistance genes from probiotic microorganisms to other microorganisms in the digestive tract.

Who should not use a probiotic? ›

Although probiotics are generally safe to use, findings of a review from 2017 suggest that children and adults with severe illnesses or compromised immune systems should avoid using probiotics. Some people with these conditions have experienced bacterial or fungal infections as a result of probiotic use.

What are the symptoms of too much probiotics? ›

Many of the bacterial strains within probiotics already exist in your gut microbiome. Even though the bacteria may be familiar to your body, it is possible to experience side effects from taking large amounts of probiotics. You may experience bloating, gas, nausea, or diarrhea when taking high amounts of probiotics.

Can you quit probiotics cold turkey? ›

There have been no rigorous scientific studies that look specifically at what happens when healthy individuals stop taking probiotics. However, if you stop populating your gut with “good” bacteria — either through supplements or food — the delicate balance can be disrupted and “bad” bacteria may begin to take over.

Can you abruptly stop taking probiotics? ›

In other words, you need to keep taking the probiotic supplements for the effects to last. If you stop taking them, your gut bacteria are likely return to their pre-supplementation condition within one to three weeks. You may be able to get longer-lasting changes by “feeding the healthy bacteria”.

Can probiotics cause more harm than good? ›

“When the gut barrier is healthy, probiotics are beneficial. When it is compromised, however, they can cause more harm than good.

Should you give your body a break from probiotics? ›

If you experience ongoing side effects from probiotics such as bloating and gas, it may be a good idea to take a break from probiotics and ensure you are taking the correct strain and dose.

Is it harmful to take probiotics every day? ›

A common question about probiotics is whether it is ok to take probiotic supplements every day. Whilst there may be a few exceptions to this rule, the general answer is yes, it's safe, and usually recommended, to take them daily. It's important to understand that probiotics are a natural supplement and not a medicine.

Why do doctors not recommend probiotics? ›

Probiotics Aren't Recommended for Most Digestive Conditions, Guidelines Say. The American Gastroenterological Association says there's no solid evidence that probiotics can treat conditions like Crohn's disease, ulcerative colitis, and irritable bowel syndrome (IBS).

When should you not have probiotics? ›

Probiotic risks

One theoretical risk of probiotics is if someone has an immune system weakened by illness or medication, that person could get sick from probiotics. Another concern about probiotics is that they're considered dietary supplements, not drugs.

Do probiotics raise blood pressure? ›

Can Probiotics and Prebiotics Lower Blood Pressure? Eating food that contains probiotics—consumable live bacteria—has been linked to healthier blood pressure in previous studies.

What happens if you take probiotics for too long? ›

Overdosing – can you take too many probiotics? There is absolutely no harm in taking probiotics in the long term, and there is generally no harm in increasing one's dose of a probiotic supplement if you feel the need.

How long does it take for your body to get used to a probiotic? ›

Depending on how sensitive you are, many people feel a difference after a few days. More fundamental effects of the probiotics such as improvements to mood, weight loss or a reduction in inflammation of your gut barrier might set in after 4-8 weeks.

How long should you take probiotics for? ›

Bottom Line: For most conditions, take probiotics for at least 3-4 weeks to see if they work for you. Acute diarrhea and food intolerances are exceptions to these guidelines.

Can I drink coffee after taking probiotics? ›

So, the simple answer is that no, you don't need to worry about taking probiotics at the same time as you are enjoying your morning coffee, though ideally, I would swallow your probiotic supplement with a sip of water, in between sips of the delicious brown stuff (or any other hot drink you like to imbibe at breakfast- ...

Can you skip a day of probiotics? ›

probiotic+ Along with taking probiotic supplements, functional medicine doctor Wendie Trubow, M.D., says it's important to eat a diverse diet rich in fiber and beneficial bacteria. As long as these nutrients are making their way into the gut, Trubow says missing a few days of a supplement won't be as big of a deal.

What are the signs that probiotics are working? ›

But there are some common indicators that they may be working for you.
  • Less stomach pain. For some people, certain probiotics can help with stomach pain and cramps. ...
  • More frequent poops. ...
  • Less bloating. ...
  • Improved sleep. ...
  • Better mood, memory, and mental clarity. ...
  • Fewer vaginal infections.
20 Jul 2022

Can you take probiotics and vitamins at the same time? ›

At recommended doses, most people can likely take probiotics and vitamins together safely. Micronutrients are more bioavailable when consumed from whole foods, so supplementing may not be necessary for healthy people who eat a varied, nutrient-rich diet.

Can I eat yogurt and take probiotics? ›

While one is in food (such as yogurt and cheese), you can also take probiotic supplements.

Should you take a break from probiotics? ›

If you experience ongoing side effects from probiotics such as bloating and gas, it may be a good idea to take a break from probiotics and ensure you are taking the correct strain and dose.

What to expect after starting a probiotic? ›

Because microbes used as probiotics already exist naturally in your body, probiotic foods and supplements are generally considered safe. They may trigger allergic reactions, and may also cause mild stomach upset, diarrhea, or flatulence (passing gas) and bloating for the first few days after starting to take them.

How long does it take for your gut to adjust to probiotics? ›

The short answer: It takes most people 2 to 3 weeks to feel significant benefits when they start taking probiotics. That's because probiotics need time to accomplish their three key goals: increase your good bacteria count, decrease your bad bacteria count, and reduce inflammation.

What happens when you stop using probiotics? ›

When probiotics administration is suspended, the probiotic cells are rapidly released, resulting in dysbiosis of the gut microbiome and disruption of the intestinal metabolites and physical function.

How long after taking a probiotic can you drink coffee? ›

“Don't take a probiotic supplement with hot food and drinks such as tea or coffee as this can lessen the chance of the bacteria getting to your gut unharmed. Give it 30 minutes after taking them before you reach for the teapot.”

Can you take vitamin D with probiotic? ›

In addition, probiotics might have synergistic effects with vitamin D, through improving the expression of vitamin D receptors [9]. Therefore, modulating the microbiota-gut-brain axis by probiotics plus improving vitamin D levels might provide a novel target to treat mental and metabolic disorders.

How long should you take probiotics? ›

Bottom Line: For most conditions, take probiotics for at least 3-4 weeks to see if they work for you. Acute diarrhea and food intolerances are exceptions to these guidelines.

What is the proper way to take probiotics? ›

Probiotics are most effective when taken on an empty stomach. Taking probiotics at least 30 minutes before a meal will reduce the time it takes for the good bacteria to get to your gut. Probiotics are dietary supplements containing beneficial bacteria naturally occurring in your intestinal tract.

Does coffee affect probiotics? ›

Typically, the heat and acidity from coffee can kill probiotics, and the study researchers say probiotic coffee should be consumed cold. This also means that simply adding a probiotic supplement to hot coffee may just negate the health benefits.

Is Greek yogurt the same as probiotic? ›

Although yogurts, such as Greek yogurt, may be teeming with organisms used as starter cultures (such as Lactobacillus bulgaricus and Streptococcus thermophilus), these are not necessarily "probiotic" organisms, i.e., those which seem to survive passage through the stomach and populate the gut for beneficial effect.

Is eating Greek yogurt the same as taking probiotics? ›

Even though the strains of naturally-occurring probiotics in yogurt are beneficial, your yogurt may simply not have enough of it to be helpful. In order to receive the full benefit of probiotic potency, you'd need to eat more than a dozen yogurts to match the potency of an adult dose of LoveBug probiotics.


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